CD300a, also known as IRp60, is an inhibitory receptor expressed by leukocytes that belongs to the CD300 family of molecules (Borrego, Blood, 2013, 121(11): 1951–60). The CD300 family of receptors is a group of eight type-I membrane glycoproteins that harbor a single IgV-like extracellular domain and regulate a diverse array of immune processes. CD300a recognizes cell surface-exposed aminophospholipids, particularly phosphatidylserine and phosphatidylethanolamine (Clark GJ, Trends Immunol, 2009; 30(5):209-217). CD300a elicits inhibitory signals via immuno-receptor tyrosine-based inhibitory motifs (ITIMs) in the cytoplasmic tail. Our anti-CD300a antibody IRP60.03 works in ELISA (on immunogen) and FACS (as described in Lankry et al, J Immunol, 2010; 185;2877-2886).

FORM	Liquid
STORAGE	Long term -20 °C, short term +4 °C. Avoid freeze-thaw cycles.
CONCENTRATION	1 mg/mL
PURITY	Affinity purified
CLONALITY	Monoclonal
ISOTYPE	IgG1
LIGHT CHAIN TYPE	kappa
REFERENCES	J Immunol 2010; 185; 2877-2886; Dikla Lankry et al.

Protocols