Mouse NKp46, also known as NCR-1, CD335 or MAR-1, is an activating receptor, member of the natural cytotoxicity receptor (NCR) family that triggers lytic activities of NK cells. It is a a type I transmembrane glycoprotein with 2 Ig-like domains and a short cytoplasmic tail, expressed almost exclusively by NK cells in both resting and activated states, allowing their discrimination from NKT cells. Furthermore, unlike for many of the other NK markers, staining with NCR-1 is not strain specific. NKp46 has been shown to play a role in NK cell-mediated lysis of several tumor cells and virus-infected cells through its capacity to bind to viral hemagglutinins. Our anti-mNCR-1 antibody mNCR1.05 is validated for ELISA (on the immunogen) and for FACS (on mouse NK cells).
Catalog No.: HR-Lympho-12
Host Species: Mouse
Antigen/Immunogen: The immunogen consisted of mNCR-1 ectodomain fused to the hIgG1 Fc fragment and and was produced from the supernatant of HEK 293T cells
Tested Applications: ELISA; FACS
Recommended Dilution: n/a
The immunogen consisted of mNCR-1 ectodomain fused to the hIgG1 Fc fragment and and was produced from the supernatant of HEK 293T cells
€120.00 – €500.00
|STORAGE||Long term -20 °C, short term +4 °C. Avoid freeze-thaw cycles.|
|LIGHT CHAIN TYPE||kappa|
V-set and transmembrane domain containing 1 (VSTM1) encodes two main splicing isoforms, VSTM1-v1 and VSTM1-v2 (Guo, Cell Immunol 2012, 278: 136–142; Steevels, J Immunol. 2010;184:4741–8).
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by <1-8% NK cells and subsets of CD8+ T cells (Melero et al., 1994, The Journal of Immunology, 152(4)).
PSG1 is the most abundantly expressed of the 11 different pregnancy-specific glycoproteins (PSGs) which are members immunoglobulin superfamily (Blois, Mucosal Immunol, 2014; 7:348–358).
Human activating receptor natural-killer group 2, member D (NKG2D) is a 35 kDa type II transmembrane glycoprotein and a part of CD94/NKG2 family of C-type lectin-like receptors