The monoclonal antibody mNCR1.05 recognizes mouse NKp46, also known as NCR-1, CD335 or MAR-1.
NKp46, a member of the natural cytotoxicity receptor (NCR) family, is a glycoprotein with 2 Ig-like domains and a short cytoplasmic tail. Expression of NKp46 is uniquely found on NK cells (including both resting and activated NK cells), and thereby allowing discrimination between NKT cells and NK cells. Furthermore, unlike many of the NK markers which also stain NKT cells, staining with NKp46 Ab is not strain specific. NKp46 has been shown to play a role in NK cell-mediated lysis of several tumor cells and pathogen-infected cell lines. Our anti-mNCR-1 antibody mNCR1.05 has been validated in ELISA (immunogen) and in flow cytometry (mouse NK cells).