The monoclonal antibody m04.10 recognizes MCMV protein m04, also known as gp34.
m04 is a 34-kDa type I glycoprotein, member of MCMV m04-m16 family that plays a role in MHC-I trafficking and immune evasion. m04 protein is abundantly expressed in the endoplasmic reticulum with early kinetics of expression (2h), peaking at 4h post infection (Kleijnen, MF et al, The EMBO Journal. 1997). m04 binds to major histocompatibility complex class I in the ER and escorts MHC I to the cell surface in order to prevent NK cell activation and killing. It is one of the most abundantly produced MCMV proteins with great number of polymorphic variants identified in MCMV field isolates (Smith, LM et al, Virology. 2006).
Our anti-m04 antibody has been validated in ELISA (immunogen) and in Western blot (MCMV infected cell lysates).