ORF63 protein is 278 aa tegument protein expressed as an immediate-early protein (J Gen Virol 1986. 67 (Pt 9): 1759-1816, J Virol 1995. 69: 4274-4282) and a homolog of herpes simplex type 1 (HSV-1) ICP22. ORF63 is one of the most abundantly expressed genes during latency and is critical for the establishment of the latency (J Virol 2004. 78: 11833-11840). ORF63 protein acts as transcriptional repressor and activator of host and viral promoters, inhibits interferon-alpha induced antiviral response (J Virol 2007. 81: 7844-7851) and supresses apoptosis of infected neurons (J Virol 2006. 80: 1025-1031). Our anti-VZV63 antibody VZ 63.08 works in ELISA (on immunogen), IF (on VZV infected cells) and each LOT is validated for Western blot of VZV infected cell lysates, where it gives a pattern as described in J Virol. 2013 Jun;87(12):6943-54.
Clone: VZ 63.08
Catalog No.: HR-VZV-33
Host Species: Mouse
Reactivity: Varicella zoster virus
Antigen/Immunogen: The immunogen consisted of full length ORF63 protein and was produced in E.coli
Tested Applications: ELISA; WB
Varicella zoster virus
The immunogen consisted of full length ORF63 protein and was produced in E.coli
€120.00 – €500.00
|STORAGE||Long term -20 °C, short term +4 °C. Avoid freeze-thaw cycles.|
|LIGHT CHAIN TYPE||kappa|
|REFERENCES||Lenac et al., J Virol, 2013|
VZV ORF27 encodes a nuclear egress lamina protein, that together with the nuclear egress membrane protein encoded by the product of VZV ORF27, most likely plays a role in the egress of assembled viral capsids from the nuclei of VZV infected cells to the cytoplasm.