ORF63 protein is 278 aa tegument protein expressed as an immediate-early protein (J Gen Virol 1986. 67 (Pt 9): 1759-1816, J Virol 1995. 69: 4274-4282) and a homolog of herpes simplex type 1 (HSV-1) ICP22. ORF63 is one of the most abundantly expressed genes during latency and is critical for the establishment of the latency (J Virol 2004. 78: 11833-11840). ORF63 protein acts as transcriptional repressor and activator of host and viral promoters, inhibits interferon-alpha induced antiviral response (J Virol 2007. 81: 7844-7851) and supresses apoptosis of infected neurons (J Virol 2006. 80: 1025-1031). Our anti-VZV63 antibody VZ 63.08 works in ELISA (on immunogen), IF (on VZV infected cells) and each LOT is validated for Western blot of VZV infected cell lysates, where it gives a pattern as described in J Virol. 2013 Jun;87(12):6943-54.
Clone: VZ 63.08
Catalog No.: HR-VZV-33
Host Species: Mouse
Reactivity: Varicella zoster virus
Antigen/Immunogen: The immunogen consisted of full length ORF63 protein and was produced in E.coli
Tested Applications: ELISA; WB
Varicella zoster virus
The immunogen consisted of full length ORF63 protein and was produced in E.coli
€120.00 – €500.00
|STORAGE||Long term -20 °C, short term +4 °C. Avoid freeze-thaw cycles.|
|LIGHT CHAIN TYPE||kappa|
|REFERENCES||Lenac et al., J Virol, 2013|
VZV ORF18 (UniProtKB – Q6QCN7) encodes a small subunit of the viral ribonucleotide reductase, which together with the large subunit, encoded by the VZV ORF19, forms the ribonucleotide reductase holoenzyme complex (RNR)
VZV ORF23 encodes a 24 kDa small capsid surface protein that localizes primarily to cell nuclei during infection and is not essential for viral replication in cell culture, even though its absence disrupts the capsid assembly.