Open reading frame 37 (ORF37) of Varicella zoster encodes for envelope glycoprotein H (gH). VZV gH is a 118kDa type 1 transmembrane glycoprotein highly conserved among other alphaherpesviruses. VZV gH forms heterodimer with gL (ORF60) and together with gB (ORF31) makes a core fusion machinery required for cell fusion and forming syncytia (Viruses (2012) 4, 800-32). To be functionally competent VZV gH needs chaperone activity of gL. VZV gH is transported and inserted within the plasma membrane, and it was shown that it is endocytosed thus regulating extent of cell-cell fusion (Journal of Virology (2004) 78, 2884–2896). Our anti-VZV ORF37 antibody VZ37.12 works in ELISA (on immunogen) and each LOT is validated for Western blot (of VZV infected cell lysates, described in J Virol. 2013 Jun;87(12):6943-54.).
Clone: VZ 37.12
Catalog No.: HR-VZV-22
Host Species: Mouse
Reactivity: Varicella zoster virus
Antigen/Immunogen: The immunogen was VZV ORF37 protein.
Tested Applications: ELISA; WB
Recommended Dilution: n/a
Varicella zoster virus
The immunogen was VZV ORF37 protein.
€200.00 – €700.00
|STORAGE||Long term -20 °C, short term +4 °C. Avoid freeze-thaw cycles.|
|LIGHT CHAIN TYPE||kappa|
|REFERENCES||Lenac et al., J Virol, 2013|
VZV ORF23 encodes a 24 kDa small capsid surface protein that localizes primarily to cell nuclei during infection and is not essential for viral replication in cell culture, even though its absence disrupts the capsid assembly.
ORF31 is one of five glycoprotein ORFs in VZV genome. It encodes for gB, a type I membrane protein containing 868 aa which in mature form exists as a highly glycosylated disulfide-linked heterodimer (Annu Rev Microbiol 1990. 44: 59-80).
VZV ORF18 (UniProtKB – Q6QCN7) encodes a small subunit of the viral ribonucleotide reductase, which together with the large subunit, encoded by the VZV ORF19, forms the ribonucleotide reductase holoenzyme complex (RNR)