VZV ORF11 encodes a tegument protein, an orthologue of HSV1 protein UL47 which is highly conserved among alphaherpesviruses. Che et al. used deletion mutant to show that ORF11 an important VZV virulence determinant for skin (J. Virol. 82, 5825–5834 (2008).). Only rabbit sera was available to analyze the ORF11 before we generated VZV mAbeom. Our anti-VZV11 antibody VZ 11N.12 shows that during infection VZV ORF11 protein localizes to Golgi network. Our anti-VZV11 antibody VZ 11N.12 works in ELISA (on immunogen), IF (on VZV infected cells) and each LOT is validated for Western blot of VZV infected lysates, where itrecognizes a protein of ~110 kDa (described in J Virol. 2013 Jun;87(12):6943-54.).
Clone: VZ 11N.12
Catalog No.: HR-VZV-07
Host Species: Mouse
Reactivity: Varicella zoster virus
Antigen/Immunogen: The immunogen consisted of ORF11 N terminal domain (amino acids 1-400) and was produced in E.coli
Tested Applications: ELISA; IF; WB
Recommended Dilution: n/a
Varicella zoster virus
The immunogen consisted of ORF11 N terminal domain (amino acids 1-400) and was produced in E.coli
ELISA; IF; WB
€200.00 – €700.00
|STORAGE||Long term -20 °C, short term +4 °C. Avoid freeze-thaw cycles.|
|LIGHT CHAIN TYPE||kappa|
|REFERENCES||Lenac et al., J Virol, 2013|
VZV ORF21 encodes a 115 kDa protein that is essential for viral replication in cell culture and is also expressed during, but is not required for establishment of latency in dorsal root and cranial nerve ganglia.
VZV ORF4 encodes an IE4 protein that acts as transactivator of several immediate early, early and late VZV genes. Dimerization of IE4 is required for its transactivation function.
ORF48 encodes an alkaline nuclease (J Virol. 87: 11936-11938). ORF48 protein is homologous to herpes simplex type 1 (HSV-1) UL12, human cytomegalovirus (hCMV) UL98 and Epstein Barr virus (EBV) BGLF5.