VZV ORF11 encodes a tegument protein, an orthologue of HSV1 protein UL47 which is highly conserved among alphaherpesviruses. Che et al. used deletion mutant to show that ORF11 an important VZV virulence determinant for skin (J. Virol. 82, 5825–5834 (2008).). Only rabbit sera was available to analyze the ORF11 before we generated VZV mAbeom. Our anti-VZV11 antibody VZ 11N.12 shows that during infection VZV ORF11 protein localizes to Golgi network. Our anti-VZV11 antibody VZ 11N.12 works in ELISA (on immunogen), IF (on VZV infected cells) and each LOT is validated for Western blot of VZV infected lysates, where itrecognizes a protein of ~110 kDa (described in J Virol. 2013 Jun;87(12):6943-54.).
Clone: VZ 11N.12
Catalog No.: HR-VZV-07
Host Species: Mouse
Reactivity: Varicella zoster virus
Antigen/Immunogen: The immunogen consisted of ORF11 N terminal domain (amino acids 1-400) and was produced in E.coli
Tested Applications: ELISA; IF; WB
Recommended Dilution: n/a
Varicella zoster virus
The immunogen consisted of ORF11 N terminal domain (amino acids 1-400) and was produced in E.coli
ELISA; IF; WB
€200.00 – €700.00
|STORAGE||Long term -20 °C, short term +4 °C. Avoid freeze-thaw cycles.|
|LIGHT CHAIN TYPE||kappa|
|REFERENCES||Lenac et al., J Virol, 2013|
Immediate-early 62 protein (IE62) is a homolog of herpes simplex type 1 (HSV-1) ICP4. These two proteins have conserved DNA bidnding domain,while not activation domain (J Virol 1993. 67: 4246-4251).
Open reading frame 37 (ORF37) of Varicella zoster encodes for envelope glycoprotein H (gH). VZV gH is a 118kDa type 1 transmembrane glycoprotein highly conserved among other alphaherpesviruses.
VZV ORF19 encodes a large, N-terminal subunit 1 of the viral ribonucleotide reductase, which together with the small subunit, encoded by the VZV ORF 18, forms the ribonucleotide reductase holoenzyme complex (RNR).