VZV ORF23 encodes a 24 kDa small capsid surface protein that localizes primarily to cell nuclei during infection and is not essential for viral replication in cell culture, even though its absence disrupts the capsid assembly. VZV ORF23 protein is located on the outer side (tips) of nucleocapsid hexons and is apparently required for the transport of major VZV capsid protein, encoded by ORF 40, to nuclei of VZV infected cells. The absence of ORF23 encoded protein prevented the VZV infection of human skin xenografts, indicating that ORF23 is required for VZV pathogenesis in vivo, making the corresponding protein an attractive target for antiviral biopharmaceuticals, including monoclonal antibodies, against VZV. Our anti-VZV ORF23 antibody VZ 23.07 works in ELISA (on immunogen), IF (on VZV infected cells) and each LOT is validated for Western blot (of VZV infected cell lysates) (described in J Virol. 2013 Jun;87(12):6943-54.).
Clone: VZ 23.07
Catalog No.: HR-VZV-12
Host Species: Mouse
Reactivity: Varicella zoster virus
Antigen/Immunogen: The immunogen consisted of full length ORF23 and was produced in E.coli
Tested Applications: ELISA; WB
Recommended Dilution: n/a
Varicella zoster virus
The immunogen consisted of full length ORF23 and was produced in E.coli
€200.00 – €700.00
|STORAGE||Long term -20 °C, short term +4 °C. Avoid freeze-thaw cycles.|
|LIGHT CHAIN TYPE||kappa|
|REFERENCES||Lenac et al., J Virol, 2013|
VZV ORF19 encodes a large, N-terminal subunit 1 of the viral ribonucleotide reductase, which together with the small subunit, encoded by the VZV ORF 18, forms the ribonucleotide reductase holoenzyme complex (RNR).
The ORF53, which is predicted to be a tegument protein, consists of 331 amino acids and plays a critical role in cytoplasmic virus egress. ORF53 participates in the final step of tegumentation and envelope acquisition within the host cytoplasm.
VZV ORF4 encodes an IE4 protein that acts as transactivator of several immediate early, early and late VZV genes. Dimerization of IE4 is required for its transactivation function.