VZV ORF23 encodes a 24 kDa small capsid surface protein that localizes primarily to cell nuclei during infection and is not essential for viral replication in cell culture, even though its absence disrupts the capsid assembly. VZV ORF23 protein is located on the outer side (tips) of nucleocapsid hexons and is apparently required for the transport of major VZV capsid protein, encoded by ORF 40, to nuclei of VZV infected cells. The absence of ORF23 encoded protein prevented the VZV infection of human skin xenografts, indicating that ORF23 is required for VZV pathogenesis in vivo, making the corresponding protein an attractive target for antiviral biopharmaceuticals, including monoclonal antibodies, against VZV. Our anti-VZV ORF23 antibody VZ 23.07 works in ELISA (on immunogen), IF (on VZV infected cells) and each LOT is validated for Western blot (of VZV infected cell lysates) (described in J Virol. 2013 Jun;87(12):6943-54.).
Clone: VZ 23.07
Catalog No.: HR-VZV-12
Host Species: Mouse
Reactivity: Varicella zoster virus
Antigen/Immunogen: The immunogen consisted of full length ORF23 and was produced in E.coli
Tested Applications: ELISA; WB
Varicella zoster virus
The immunogen consisted of full length ORF23 and was produced in E.coli
€120.00 – €500.00
|STORAGE||Long term -20 °C, short term +4 °C. Avoid freeze-thaw cycles.|
|LIGHT CHAIN TYPE||kappa|
|REFERENCES||Lenac et al., J Virol, 2013|
VZV ORF21 encodes a 115 kDa protein that is essential for viral replication in cell culture and is also expressed during, but is not required for establishment of latency in dorsal root and cranial nerve ganglia.
VZV ORF24 encodes a 30 kDa type 2 membrane protein that, together with the product of VZV ORF27, likely has a function in the transport (egress) of assembled viral capsids from the nuclei of VZV infected cells to the cytoplasm.
VZV ORF19 encodes a large, N-terminal subunit 1 of the viral ribonucleotide reductase, which together with the small subunit, encoded by the VZV ORF 18, forms the ribonucleotide reductase holoenzyme complex (RNR).
VZV ORF33.5 encodes a scaffold protein involved in the assembly of the viral capsid. ORF33.5 has the capacity to mediate ORF40 translocation into the nucleus of VZV-infected cells and exhibits a nuclear localization phenotype.