VZV ORF4 encodes an IE4 protein that acts as transactivator of several immediate early, early and late VZV genes. Dimerization of IE4 is required for its transactivation function. During the initial phase of viral infection, it mainly localizes in the nucleus, whereas later in infection it localizes in the cytoplasm. IE4 is a phosphoprotein of approximately 50kDa and together with IE62 and IE63 constitutes a viral tegument. IE4 is an essential factor for viral replication and for the establishment of a latent infection. Our anti VZV ORF4 antibody VZ 4.05 works in ELISA (on immunogen), in IF (on VZV infected cells) and each LOT is validated for Western blot on VZV infected cell lysates where it gives a pattern as described in J Virol. 2013 Jun;87(12):6943-54.
Clone: VZ 4.05
Catalog No.: HR-VZV-20
Host Species: Mouse
Reactivity: Varicella zoster virus
Antigen/Immunogen: The immunogen consisted of full length ORF4 and was produced in E.coli
Tested Applications: ELISA; WB
Recommended Dilution: n/a
Varicella zoster virus
The immunogen consisted of full length ORF4 and was produced in E.coli
€200.00 – €700.00
|STORAGE||Long term -20 °C, short term +4 °C. Avoid freeze-thaw cycles.|
|LIGHT CHAIN TYPE||n/a|
|REFERENCES||Lenac et al., J Virol, 2013|
VZV ORF24 encodes a 30 kDa type 2 membrane protein that, together with the product of VZV ORF27, likely has a function in the transport (egress) of assembled viral capsids from the nuclei of VZV infected cells to the cytoplasm.
VZV ORF18 (UniProtKB – Q6QCN7) encodes a small subunit of the viral ribonucleotide reductase, which together with the large subunit, encoded by the VZV ORF19, forms the ribonucleotide reductase holoenzyme complex (RNR)
The ORF53, which is predicted to be a tegument protein, consists of 331 amino acids and plays a critical role in cytoplasmic virus egress. ORF53 participates in the final step of tegumentation and envelope acquisition within the host cytoplasm.