VZV ORF4 encodes an IE4 protein that acts as transactivator of several immediate early, early and late VZV genes. Dimerization of IE4 is required for its transactivation function. During the initial phase of viral infection, it mainly localizes in the nucleus, whereas later in infection it localizes in the cytoplasm. IE4 is a phosphoprotein of approximately 50kDa and together with IE62 and IE63 constitutes a viral tegument. IE4 is an essential factor for viral replication and for the establishment of a latent infection. Our anti VZV ORF4 antibody VZ 4.05 works in ELISA (on immunogen), in IF (on VZV infected cells) and each LOT is validated for Western blot on VZV infected cell lysates where it gives a pattern as described in J Virol. 2013 Jun;87(12):6943-54.
Clone: VZ 4.05
Catalog No.: HR-VZV-20
Host Species: Mouse
Reactivity: Varicella zoster virus
Antigen/Immunogen: The immunogen consisted of full length ORF4 and was produced in E.coli
Tested Applications: ELISA; WB
Recommended Dilution: n/a
Varicella zoster virus
The immunogen consisted of full length ORF4 and was produced in E.coli
€200.00 – €700.00
|STORAGE||Long term -20 °C, short term +4 °C. Avoid freeze-thaw cycles.|
|LIGHT CHAIN TYPE||n/a|
|REFERENCES||Lenac et al., J Virol, 2013|
The ORF50 gene of the varicella-zoster virus (VZV) encodes glycoprotein M which is conserved among all herpesviruses. VZV gM is predicted to be an eight-transmembrane envelope glycoprotein modified with a complex N-linked oligosaccharide.
VZV ORF27 encodes a nuclear egress lamina protein, that together with the nuclear egress membrane protein encoded by the product of VZV ORF27, most likely plays a role in the egress of assembled viral capsids from the nuclei of VZV infected cells to the cytoplasm.
ORF48 encodes an alkaline nuclease (J Virol. 87: 11936-11938). ORF48 protein is homologous to herpes simplex type 1 (HSV-1) UL12, human cytomegalovirus (hCMV) UL98 and Epstein Barr virus (EBV) BGLF5.
Open reading frame 37 (ORF37) of Varicella zoster encodes for envelope glycoprotein H (gH). VZV gH is a 118kDa type 1 transmembrane glycoprotein highly conserved among other alphaherpesviruses.