VZV ORF41 encodes a ~34 kDa protein that is packaged into the nucleocapsid core of the VZV virions together with protein products of ORFs 20, 21, 23, 33 and 40. By employing multiplex mRNA RT-PCR analysis, it has been shown that ORF41 belongs to the group of VZV genes latently expressed in trigeminal ganglia. Protein product of the VZV ORF41 plays a role in capsid morphogenesis by forming a 2:1 protein complex with capsid triplex subunit 1 thereby connecting nucleocapsid hexons and pentons in the VZV virions. Our anti-VZV ORF41 antibody VZ 41.01 works in ELISA (on immunogen) and each LOT is validated for Western blot of VZV infected cell lysates (described in J Virol. 2013 Jun;87(12):6943-54.).
Clone: VZ 41.01
Catalog No.: HR-VZV-16
Host Species: Mouse
Reactivity: Varicella zoster virus
Antigen/Immunogen: The immunogen consisted of full length ORF41 and was produced in E.coli
Tested Applications: ELISA; WB
Recommended Dilution: n/a
Varicella zoster virus
The immunogen consisted of full length ORF41 and was produced in E.coli
€200.00 – €700.00
|STORAGE||Long term -20 °C, short term +4 °C. Avoid freeze-thaw cycles.|
|LIGHT CHAIN TYPE||kappa|
|REFERENCES||Lenac et al., J Virol, 2013|
The ORF50 gene of the varicella-zoster virus (VZV) encodes glycoprotein M which is conserved among all herpesviruses. VZV gM is predicted to be an eight-transmembrane envelope glycoprotein modified with a complex N-linked oligosaccharide.
VZV ORF18 (UniProtKB – Q6QCN7) encodes a small subunit of the viral ribonucleotide reductase, which together with the large subunit, encoded by the VZV ORF19, forms the ribonucleotide reductase holoenzyme complex (RNR)
Immediate-early 62 protein (IE62) is a homolog of herpes simplex type 1 (HSV-1) ICP4. These two proteins have conserved DNA bidnding domain,while not activation domain (J Virol 1993. 67: 4246-4251).
VZV ORF21 encodes a 115 kDa protein that is essential for viral replication in cell culture and is also expressed during, but is not required for establishment of latency in dorsal root and cranial nerve ganglia.
VZV ORF4 encodes an IE4 protein that acts as transactivator of several immediate early, early and late VZV genes. Dimerization of IE4 is required for its transactivation function.