VZV ORF41 encodes a ~34 kDa protein that is packaged into the nucleocapsid core of the VZV virions together with protein products of ORFs 20, 21, 23, 33 and 40. By employing multiplex mRNA RT-PCR analysis, it has been shown that ORF41 belongs to the group of VZV genes latently expressed in trigeminal ganglia. Protein product of the VZV ORF41 plays a role in capsid morphogenesis by forming a 2:1 protein complex with capsid triplex subunit 1 thereby connecting nucleocapsid hexons and pentons in the VZV virions. Our anti-VZV ORF41 antibody VZ 41.01 works in ELISA (on immunogen) and each LOT is validated for Western blot of VZV infected cell lysates (described in J Virol. 2013 Jun;87(12):6943-54.).
Clone: VZ 41.01
Catalog No.: HR-VZV-16
Host Species: Mouse
Reactivity: Varicella zoster virus
Antigen/Immunogen: The immunogen consisted of full length ORF41 and was produced in E.coli
Tested Applications: ELISA; WB
Varicella zoster virus
The immunogen consisted of full length ORF41 and was produced in E.coli
€120.00 – €500.00
|STORAGE||Long term -20 °C, short term +4 °C. Avoid freeze-thaw cycles.|
|LIGHT CHAIN TYPE||kappa|
|REFERENCES||Lenac et al., J Virol, 2013|
ORF31 is one of five glycoprotein ORFs in VZV genome. It encodes for gB, a type I membrane protein containing 868 aa which in mature form exists as a highly glycosylated disulfide-linked heterodimer (Annu Rev Microbiol 1990. 44: 59-80).
Open reading frame 37 (ORF37) of Varicella zoster encodes for envelope glycoprotein H (gH). VZV gH is a 118kDa type 1 transmembrane glycoprotein highly conserved among other alphaherpesviruses.
ORF48 encodes an alkaline nuclease (J Virol. 87: 11936-11938). ORF48 protein is homologous to herpes simplex type 1 (HSV-1) UL12, human cytomegalovirus (hCMV) UL98 and Epstein Barr virus (EBV) BGLF5.
VZV ORF23 encodes a 24 kDa small capsid surface protein that localizes primarily to cell nuclei during infection and is not essential for viral replication in cell culture, even though its absence disrupts the capsid assembly.
The ORF50 gene of the varicella-zoster virus (VZV) encodes glycoprotein M which is conserved among all herpesviruses. VZV gM is predicted to be an eight-transmembrane envelope glycoprotein modified with a complex N-linked oligosaccharide.