VZV ORF58 is located at the 3′ UL region of the Varicella Zoster Virus genome and encodes a 25 kDa protein with an unknown function. It is a nuclear phosphoprotein shown to be dispensable for viral replication in vitro (Yoshii et al., 2008, Journal of Virology). Our anti VZV ORF58 antibody VZ 58.01 works in ELISA (on immunogen), in IF (on VZV infected cells) and each LOT is validated for Western blot on VZV infected cell lysates where it gives a pattern as described in J Virol. 2013 Jun;87(12):6943-54.
Clone: VZ 58.01
Catalog No.: HR-VZV-19
Host Species: Mouse
Reactivity: Varicella zoster virus
Antigen/Immunogen: The immunogen consisted of full length ORF58 fused with MBP and was produced in E.coli
Tested Applications: ELISA; WB
Varicella zoster virus
The immunogen consisted of full length ORF58 fused with MBP and was produced in E.coli
€120.00 – €500.00
|STORAGE||Long term -20 °C, short term +4 °C. Avoid freeze-thaw cycles.|
|LIGHT CHAIN TYPE||kappa|
|REFERENCES||Lenac et al., J Virol, 2013|
VZV ORF4 encodes an IE4 protein that acts as transactivator of several immediate early, early and late VZV genes. Dimerization of IE4 is required for its transactivation function.
VZV ORF24 encodes a 30 kDa type 2 membrane protein that, together with the product of VZV ORF27, likely has a function in the transport (egress) of assembled viral capsids from the nuclei of VZV infected cells to the cytoplasm.
VZV ORF23 encodes a 24 kDa small capsid surface protein that localizes primarily to cell nuclei during infection and is not essential for viral replication in cell culture, even though its absence disrupts the capsid assembly.