Anti-human LIR1 antibody

LIR-1 is an inhibitory receptor also known as immunoglobulin-like transcript 2 (ILT-2)/CD85j or leukocyte immunoglobulin-like receptor, subfamily B member 1 (LILRB1). LIR receptors are type I transmembrane proteins of the immunoglobulin-like receptor superfamily (Cosman, Immunity, 7 (1997), pp. 273–282). They recognize classical HLA class I molecules, while LIR-1 can also interact with nonclassical HLA class I and bacteria with low binding affinities (Cytokine and Growth Factor Reviews, vol. 11, no. 3, pp. 209–217, 2000). LIRs are expressed on subsets of NK cells and T cells, as well as on monocytes, B cells, and DC, with the widest distribution for LIR-1 (Nakayama, Journal of Immunology, vol. 178, no. 7, pp. 4250–4259, 2007). Our anti-LIR-1 antibody LIR1.14 works in ELISA (on immunogen), IF and FACS (on human cells).