Anti-human CMRF (cd300c) antibody
Clone: CMRF-2.13(08)
Catalog No.: HR-Lympho-10
Host Species: Mouse
Reactivity: Human
Antigen/Immunogen: The immunogen consisted of CD300c ectodomain fused to the hIgG1 Fc fragment and was produced from the supernatant of HEK 293T cells
Tested Applications: ELISA, FACS
€200.00 – €1,500.00
Anti-human CMRF (cd300c) antibody
FACS analysis of bulk NK culture with anti-CMRF (cd300c).
Anti-human CMRF (cd300c) antibody
FACS analysis of YTS cells expressing CD300a with anti-CMRF (cd300c).
Anti-human CMRF (cd300c) antibody
Overlay histogram showing CD56+ hPBMCs stained with 1:100 CMRF2.13 Ab (red line) and FITC-conjugated anti-mouse IgG. Isotype control antibody (black line) was mouse IgG used under the same conditions.
Anti-human CMRF (cd300c) antibody
FACS analysis of YTS cells expressing CD300a with anti-CMRF (cd300c).
Anti-human CMRF (cd300c) antibody
Overlay histogram showing CD56+ hPBMCs stained with 1:100 CMRF2.13 Ab (red line) and FITC-conjugated anti-mouse IgG. Isotype control antibody (black line) was mouse IgG used under the same conditions.
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Description
CD300c is an activating receptor expressed by leukocytes that belongs to the CD300 family of molecules (Borrego, Blood, 2013, 121(11): 1951–60). The CD300 family of receptors is a group of eight type-I membrane glycoproteins that harbor a single IgV-like extracellular domain and regulate a diverse array of immune processes. The human activating receptor CD300c has a short cytoplasmic tail, a negatively charged amino acid residue in the transmembrane region and the potential to to signal via adaptor molecules FcεRIγ and DAP12 (Clark GJ, Trends Immunol, 2009; 30(5):209-217).
Our anti-CD300c antibody CMRF-2.13(08) works in ELISA (on immunogen) and FACS (as described in Lankry et al, J Immunol, 2010; 185;2877-2886).
Additional information
| FORM | Liquid, in PBS |
|---|---|
| STORAGE | Long term -20 °C, short term +4 °C. Avoid freeze-thaw cycles. |
| CONCENTRATION | 1 mg/mL |
| PURITY | Affinity purified |
| CLONALITY | Monoclonal |
| ISOTYPE | IgG1 |
| LIGHT CHAIN TYPE | kappa |
| REFERENCES | doi: 10.4049/jimmunol.0903347 |
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