ORF10 protein belongs to the herpesvirus UL49 gene family and is a homolog of the herpes simplex type 1 (HSV-1) protein VP16 (J Gen Virol 1986. 67 (Pt 9): 1759-1816). This tegument protein acts as a transactivator of the VZV ORF62 gene (J Virol 1993. 67: 2739-2746). ORF10 protein is dispensable for the VZV replication in vitro (J Virol 2006. 80: 3238-3248, J Virol 1994. 68: 7850-7858). Our anti-VZV10 antibody VZ 10.12 works in ELISA (on immunogen) and each LOT is validated for Western blot of VZV infected cell lysates, where it gives a pattern as described in J Virol. 2013 Jun;87(12):6943-54.
Clone: VZ 10.12
Catalog No.: HR-VZV-41
Host Species: Mouse
Reactivity: Varicella zoster virus
Antigen/Immunogen: The immunogen consisted of full length ORF10 protein and was produced in E.coli
Tested Applications: ELISA; WB
Recommended Dilution: WB: 1:200 - 1:1000
Varicella zoster virus
The immunogen consisted of full length ORF10 protein and was produced in E.coli
€120.00 – €500.00
|STORAGE||Long term -20 °C, short term +4 °C. Avoid freeze-thaw cycles.|
|LIGHT CHAIN TYPE||kappa|
|REFERENCES||Lenac et al., J Virol, 2013|
ORF48 encodes an alkaline nuclease (J Virol. 87: 11936-11938). ORF48 protein is homologous to herpes simplex type 1 (HSV-1) UL12, human cytomegalovirus (hCMV) UL98 and Epstein Barr virus (EBV) BGLF5.
VZV ORF21 encodes a 115 kDa protein that is essential for viral replication in cell culture and is also expressed during, but is not required for establishment of latency in dorsal root and cranial nerve ganglia.
VZV ORF33.5 encodes a scaffold protein involved in the assembly of the viral capsid. ORF33.5 has the capacity to mediate ORF40 translocation into the nucleus of VZV-infected cells and exhibits a nuclear localization phenotype.