ORF10 protein belongs to the herpesvirus UL49 gene family and is a homolog of the herpes simplex type 1 (HSV-1) protein VP16 (J Gen Virol 1986. 67 (Pt 9): 1759-1816). This tegument protein acts as a transactivator of the VZV ORF62 gene (J Virol 1993. 67: 2739-2746). ORF10 protein is dispensable for the VZV replication in vitro (J Virol 2006. 80: 3238-3248, J Virol 1994. 68: 7850-7858). Our anti-VZV10 antibody VZ 10.12 works in ELISA (on immunogen) and each LOT is validated for Western blot of VZV infected cell lysates, where it gives a pattern as described in J Virol. 2013 Jun;87(12):6943-54.
Clone: VZ 10.12
Catalog No.: HR-VZV-41
Host Species: Mouse
Reactivity: Varicella zoster virus
Antigen/Immunogen: The immunogen consisted of full length ORF10 protein and was produced in E.coli
Tested Applications: ELISA; WB
Recommended Dilution: WB: 1:200 - 1:1000
Varicella zoster virus
The immunogen consisted of full length ORF10 protein and was produced in E.coli
€120.00 – €500.00
|STORAGE||Long term -20 °C, short term +4 °C. Avoid freeze-thaw cycles.|
|LIGHT CHAIN TYPE||kappa|
|REFERENCES||Lenac et al., J Virol, 2013|
VZV ORF23 encodes a 24 kDa small capsid surface protein that localizes primarily to cell nuclei during infection and is not essential for viral replication in cell culture, even though its absence disrupts the capsid assembly.
VZV ORF19 encodes a large, N-terminal subunit 1 of the viral ribonucleotide reductase, which together with the small subunit, encoded by the VZV ORF 18, forms the ribonucleotide reductase holoenzyme complex (RNR).
ORF48 encodes an alkaline nuclease (J Virol. 87: 11936-11938). ORF48 protein is homologous to herpes simplex type 1 (HSV-1) UL12, human cytomegalovirus (hCMV) UL98 and Epstein Barr virus (EBV) BGLF5.