KIR2DS2 is an activating member of the killer cell Ig-like receptor (KIR) family (Parham, Nat. Rev. Immunol. 5: 201–214). KIRs are transmembrane glycoproteins expressed on natural killer cells that detect the major histocompatibility complex (MHC) class I on cells. KIR2DS2 contains two extracytoplasmic Ig-like domains and a short cytoplasmic tail that lacks inhibitory motifs and associates to KARAP/DAP12 polypeptides. DAP12 contains ITAM that are involved in the transduction of activating signals (Lanier, 1998, Nature 391: 703–707). Our anti-KIR2DS2 antibody KIR2DS2-2.08 works in ELISA (on immunogen) and in FACS (on human cells).
Catalog No.: HR-Lympho-06
Host Species: Mouse
Antigen/Immunogen: The immunogen consisted of KIR2DS2 ectodomain fused to the hIgG1 Fc fragment and was produced from the supernatant of HEK 293T cells
Tested Applications: ELISA; FACS
Recommended Dilution: n/a
The immunogen consisted of KIR2DS2 ectodomain fused to the hIgG1 Fc fragment and was produced from the supernatant of HEK 293T cells
€200.00 – €700.00
|STORAGE||Long term -20 °C, short term +4 °C. Avoid freeze-thaw cycles.|
|LIGHT CHAIN TYPE||kappa|
V-set and transmembrane domain containing 1 (VSTM1) encodes two main splicing isoforms, VSTM1-v1 and VSTM1-v2 (Guo, Cell Immunol 2012, 278: 136–142; Steevels, J Immunol. 2010;184:4741–8).
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by <1-8% NK cells and subsets of CD8+ T cells (Melero et al., 1994, The Journal of Immunology, 152(4)).
PSG1 is the most abundantly expressed of the 11 different pregnancy-specific glycoproteins (PSGs) which are members immunoglobulin superfamily (Blois, Mucosal Immunol, 2014; 7:348–358).
Human activating receptor natural-killer group 2, member D (NKG2D) is a 35 kDa type II transmembrane glycoprotein and a part of CD94/NKG2 family of C-type lectin-like receptors