KIR2DS2 is an activating member of the killer cell Ig-like receptor (KIR) family (Parham, Nat. Rev. Immunol. 5: 201–214). KIRs are transmembrane glycoproteins expressed on natural killer cells that detect the major histocompatibility complex (MHC) class I on cells. KIR2DS2 contains two extracytoplasmic Ig-like domains and a short cytoplasmic tail that lacks inhibitory motifs and associates to KARAP/DAP12 polypeptides. DAP12 contains ITAM that are involved in the transduction of activating signals (Lanier, 1998, Nature 391: 703–707). Our anti-KIR2DS2 antibody KIR2DS2-2.08 works in ELISA (on immunogen) and in FACS (on human cells).
Catalog No.: HR-Lympho-06
Host Species: Mouse
Antigen/Immunogen: The immunogen consisted of KIR2DS2 ectodomain fused to the hIgG1 Fc fragment and was produced from the supernatant of HEK 293T cells
Tested Applications: ELISA; FACS
Recommended Dilution: n/a
€200.00 – €700.00