During VZV infection, ORF9 is the most transcribed VZV gene (J Virol 2003. 77: 11718-11732., J Gen Virol 2005. 86: 2673-2684.). ORF9 protein is a 302 aa tegument protein expressed at late time post VZV infection and is a member of herpesvirus UL49 gene family (J Gen Virol 1986. 67 (Pt 9): 1759-1816). It has an essential role in VZV replication (J Virol 2007. 81: 13200-13208) and a role in secondary envelopment (J. Virol. 87: 2868-2881). This protein is localized in the cytoplasm and it was reported its role in the recruitment of IE62 to complexes within the cytoplasm (J Virol 2007. 81: 761-774). Our anti-VZV9 antibody VZ 9C.09 works in ELISA (on immunogen), IF (on VZV infected cells) and each LOT is validated for Western blot of VZV infected cell lysates (described in J Virol. 2013 Jun;87(12):6943-54.).
Clone: VZ 9C.09
Catalog No.: HR-VZV-38
Host Species: Mouse
Reactivity: Varicella zoster virus
Antigen/Immunogen: The immunogen consisted of ORF9 C terminal domain (amino acids 151-303) and was produced in E.coli
Tested Applications: ELISA; WB
Varicella zoster virus
The immunogen consisted of ORF9 C terminal domain (amino acids 151-303) and was produced in E.coli
€120.00 – €500.00
|STORAGE||Long term -20 °C, short term +4 °C. Avoid freeze-thaw cycles.|
|LIGHT CHAIN TYPE||kappa|
|REFERENCES||Lenac et al., J Virol, 2013|
VZV ORF24 encodes a 30 kDa type 2 membrane protein that, together with the product of VZV ORF27, likely has a function in the transport (egress) of assembled viral capsids from the nuclei of VZV infected cells to the cytoplasm.
VZV ORF4 encodes an IE4 protein that acts as transactivator of several immediate early, early and late VZV genes. Dimerization of IE4 is required for its transactivation function.
VZV ORF23 encodes a 24 kDa small capsid surface protein that localizes primarily to cell nuclei during infection and is not essential for viral replication in cell culture, even though its absence disrupts the capsid assembly.
VZV ORF18 (UniProtKB – Q6QCN7) encodes a small subunit of the viral ribonucleotide reductase, which together with the large subunit, encoded by the VZV ORF19, forms the ribonucleotide reductase holoenzyme complex (RNR)