VZV ORF7 (UniProtKB – Q6QCP9) is the ortholog of HSV-1 protein UL51. Zhang et al showed that ORF7 is required for viral replication in skin organ cultures (a skin tropism factor) (PLoS Pathog. 2010 Jul 1;6:e1000971. doi: 10.1371) and shortly Selariu et al showed how ORF7 is a neurotropic factor, where the deletion completely abolishes viral spread in human nervous tissue (J Virol. 2012 Aug;86(16):8614-24. doi: 10.1128. The later manuscript describes a monoclonal antibody to ORF7. Our monoclonal antibody to ORF7, VZ 7.05, reveals a protein with dominant localisation in Golgi networks and a dominant band around 35 kDa in western blot. Our anti-VZV ORF7 antibody VZ 7.05 works in ELISA (on immunogen), IF (on VZV infected cells) and each LOT is validated for Western blot (of VZV infected cell lysates, described in J Virol. 2013 Jun;87(12):6943-54.).
Clone: VZ 7.05
Catalog No.: HR-VZV-36
Host Species: Mouse
Reactivity: Varicella zoster virus
Antigen/Immunogen: The immunogen consisted of full length ORF7 and was produced in E.coli
Tested Applications: ELISA; WB
Varicella zoster virus
The immunogen consisted of full length ORF7 and was produced in E.coli
€120.00 – €500.00
|STORAGE||Long term -20 °C, short term +4 °C. Avoid freeze-thaw cycles.|
|LIGHT CHAIN TYPE||kappa|
|REFERENCES||Lenac et al., J Virol, 2013|
VZV ORF24 encodes a 30 kDa type 2 membrane protein that, together with the product of VZV ORF27, likely has a function in the transport (egress) of assembled viral capsids from the nuclei of VZV infected cells to the cytoplasm.
VZV ORF27 encodes a nuclear egress lamina protein, that together with the nuclear egress membrane protein encoded by the product of VZV ORF27, most likely plays a role in the egress of assembled viral capsids from the nuclei of VZV infected cells to the cytoplasm.