The monoclonal antibody VZ 63.08 recognizes VZV ORF63.

ORF63 protein is 278 amino acids long tegument protein expressed with an immediate-early kinetics (J Gen Virol 1986. 67 (Pt 9): 1759-1816, J Virol 1995. 69: 4274-4282). It is a homolog of HSV-1 protein ICP22. ORF63 is one of the most abundantly expressed genes during latency, also shown to be critical for the establishment of latency (J Virol 2004. 78: 11833-11840). ORF63 protein acts as transcriptional repressor and activator of host and viral promoters, inhibits interferon-alpha induced antiviral response (J Virol 2007. 81: 7844-7851) and supresses apoptosis of infected neurons (J Virol 2006. 80: 1025-1031).

Our anti-ORF63 antibody has been validated in ELISA (on immunogen), IF (VZV infected cells) and in WB (VZV infected cell lysates) as described in J Virol. 2013 Jun;87(12):6943-54.

FORM	Liquid
STORAGE	Long term -20 °C, short term +4 °C. Avoid freeze-thaw cycles.
CONCENTRATION	1 mg/mL
PURITY	Affinity purified
CLONALITY	Monoclonal
ISOTYPE	IgG1
LIGHT CHAIN TYPE	kappa
REFERENCES	Journal of Virology (2013) 87, 6943–6954

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