The monoclonal antibody VZ 54.08 recognizes VZV ORF54.
VZV ORF54 assembles as a dodecamer and has a role in DNA packaging (UniProtKB – Q6QCK2). Its HSV-1 homolog is UL6. Visalli et al (J. Virol. July 2014 vol. 88 no. 14 7973-7986) showed that the VZV ORF54 is essential for cleavage and packaging of viral DNA. The ORF54 monomer has predicted molecular weight of 87 kDa and our monoclonal antibody shows a doublet band at around 90 kDa in Western blot.
Our anti-ORF54 antibody has been validated in ELISA (on immunogen) and in WB (VZV infected cell lysates) as described in J Virol. 2013 Jun;87(12):6943-54.