The ORF53, which is predicted to be a tegument protein, consists of 331 amino acids and plays a critical role in cytoplasmic virus egress. ORF53 participates in the final step of tegumentation and envelope acquisition within the host cytoplasm. It is predominantly located to the trans-Golgi network of the infected host cell together with ORF7 (virion phosphoprotein). Our anti – VZV ORF 53 antibody VZ 53.12 (described in J Virol. 2013 Jun;87(12):6943-54) works in ELISA (on immunogen) and each LOT was validated for Western blot (of VZV infected cell lysates) where it specifically recognizes a protein species of ~38 kDa in lysates obtained from VZV infected cells.
Clone: VZ 53.12
Catalog No.: HR-VZV-28
Host Species: Mouse
Reactivity: Varicella zoster virus
Antigen/Immunogen: The immunogen consisted of full length ORF 53 and was produced in E.coli
Tested Applications: ELISA; WB
Recommended Dilution: n/a
Varicella zoster virus
The immunogen consisted of full length ORF 53 and was produced in E.coli
€200.00 – €700.00
|STORAGE||Long term -20 °C, short term +4 °C. Avoid freeze-thaw cycles.|
|LIGHT CHAIN TYPE||kappa|
|REFERENCES||Lenac et al., J Virol, 2013|
VZV ORF27 encodes a nuclear egress lamina protein, that together with the nuclear egress membrane protein encoded by the product of VZV ORF27, most likely plays a role in the egress of assembled viral capsids from the nuclei of VZV infected cells to the cytoplasm.
Immediate-early 62 protein (IE62) is a homolog of herpes simplex type 1 (HSV-1) ICP4. These two proteins have conserved DNA bidnding domain,while not activation domain (J Virol 1993. 67: 4246-4251).
Open reading frame 37 (ORF37) of Varicella zoster encodes for envelope glycoprotein H (gH). VZV gH is a 118kDa type 1 transmembrane glycoprotein highly conserved among other alphaherpesviruses.