The ORF53, which is predicted to be a tegument protein, consists of 331 amino acids and plays a critical role in cytoplasmic virus egress. ORF53 participates in the final step of tegumentation and envelope acquisition within the host cytoplasm. It is predominantly located to the trans-Golgi network of the infected host cell together with ORF7 (virion phosphoprotein). Our anti – VZV ORF 53 antibody VZ 53.12 (described in J Virol. 2013 Jun;87(12):6943-54) works in ELISA (on immunogen) and each LOT was validated for Western blot (of VZV infected cell lysates) where it specifically recognizes a protein species of ~38 kDa in lysates obtained from VZV infected cells.
Clone: VZ 53.12
Catalog No.: HR-VZV-28
Host Species: Mouse
Reactivity: Varicella zoster virus
Antigen/Immunogen: The immunogen consisted of full length ORF 53 and was produced in E.coli
Tested Applications: ELISA; WB
Recommended Dilution: n/a
Varicella zoster virus
The immunogen consisted of full length ORF 53 and was produced in E.coli
€200.00 – €700.00
|STORAGE||Long term -20 °C, short term +4 °C. Avoid freeze-thaw cycles.|
|LIGHT CHAIN TYPE||kappa|
|REFERENCES||Lenac et al., J Virol, 2013|
VZV ORF27 encodes a nuclear egress lamina protein, that together with the nuclear egress membrane protein encoded by the product of VZV ORF27, most likely plays a role in the egress of assembled viral capsids from the nuclei of VZV infected cells to the cytoplasm.
VZV ORF19 encodes a large, N-terminal subunit 1 of the viral ribonucleotide reductase, which together with the small subunit, encoded by the VZV ORF 18, forms the ribonucleotide reductase holoenzyme complex (RNR).
ORF48 encodes an alkaline nuclease (J Virol. 87: 11936-11938). ORF48 protein is homologous to herpes simplex type 1 (HSV-1) UL12, human cytomegalovirus (hCMV) UL98 and Epstein Barr virus (EBV) BGLF5.