ORF47 protein is a tegument protein which possesses a kinase activity (J Gen Virol 1994. 75 (Pt 2): 317-326, Virology 1992. 191: 9-18) and is a homolog of herpes simplex type 1 (HSV-1) UL13, human cytomegalovirus (hCMV) UL97 and Epstein Barr virus (EBV) BFLF4 protein kinases (J Virol 1989. 63: 450-455). This protein is essential for the T cell tropism (Proc Natl Acad Sci U S A 1998. 95: 11969-11974) and for VZV replication in immature dendritic cells (DC), but not in mature DC (Virology 2005. 337: 304-311). The ORF47 kinase was reported to form a complex with VZV IE62 (J Virol 2003. 77: 5964-5974). Our anti-VZV47 antibody VZ 47.01 works in ELISA (on immunogen), IF (on VZV infected cells) and each LOT is validated for Western blot of VZV infected cell lysates, where it gives a pattern as described in J Virol. 2013 Jun;87(12):6943-54.).
Clone: VZ 47.01
Catalog No.: HR-VZV-31
Host Species: Mouse
Reactivity: Varicella zoster virus
Antigen/Immunogen: The immunogen consisted of baculovirus-derived full length ORF47 protein
Tested Applications: ELISA; WB
Recommended Dilution: n/a
Varicella zoster virus
The immunogen consisted of baculovirus-derived full length ORF47 protein
€200.00 – €700.00
|STORAGE||Long term -20 °C, short term +4 °C. Avoid freeze-thaw cycles.|
|LIGHT CHAIN TYPE||kappa|
|REFERENCES||Lenac et al., J Virol, 2013|
VZV ORF24 encodes a 30 kDa type 2 membrane protein that, together with the product of VZV ORF27, likely has a function in the transport (egress) of assembled viral capsids from the nuclei of VZV infected cells to the cytoplasm.
VZV ORF18 (UniProtKB – Q6QCN7) encodes a small subunit of the viral ribonucleotide reductase, which together with the large subunit, encoded by the VZV ORF19, forms the ribonucleotide reductase holoenzyme complex (RNR)
VZV ORF21 encodes a 115 kDa protein that is essential for viral replication in cell culture and is also expressed during, but is not required for establishment of latency in dorsal root and cranial nerve ganglia.