ORF47 protein is a tegument protein which possesses a kinase activity (J Gen Virol 1994. 75 (Pt 2): 317-326, Virology 1992. 191: 9-18) and is a homolog of herpes simplex type 1 (HSV-1) UL13, human cytomegalovirus (hCMV) UL97 and Epstein Barr virus (EBV) BFLF4 protein kinases (J Virol 1989. 63: 450-455). This protein is essential for the T cell tropism (Proc Natl Acad Sci U S A 1998. 95: 11969-11974) and for VZV replication in immature dendritic cells (DC), but not in mature DC (Virology 2005. 337: 304-311). The ORF47 kinase was reported to form a complex with VZV IE62 (J Virol 2003. 77: 5964-5974). Our anti-VZV47 antibody VZ 47.01 works in ELISA (on immunogen), IF (on VZV infected cells) and each LOT is validated for Western blot of VZV infected cell lysates, where it gives a pattern as described in J Virol. 2013 Jun;87(12):6943-54.).
Clone: VZ 47.01
Catalog No.: HR-VZV-31
Host Species: Mouse
Reactivity: Varicella zoster virus
Antigen/Immunogen: The immunogen consisted of baculovirus-derived full length ORF47 protein
Tested Applications: ELISA; WB
Recommended Dilution: n/a
Varicella zoster virus
The immunogen consisted of baculovirus-derived full length ORF47 protein
€200.00 – €700.00
|STORAGE||Long term -20 °C, short term +4 °C. Avoid freeze-thaw cycles.|
|LIGHT CHAIN TYPE||kappa|
|REFERENCES||Lenac et al., J Virol, 2013|
ORF48 encodes an alkaline nuclease (J Virol. 87: 11936-11938). ORF48 protein is homologous to herpes simplex type 1 (HSV-1) UL12, human cytomegalovirus (hCMV) UL98 and Epstein Barr virus (EBV) BGLF5.
VZV ORF27 encodes a nuclear egress lamina protein, that together with the nuclear egress membrane protein encoded by the product of VZV ORF27, most likely plays a role in the egress of assembled viral capsids from the nuclei of VZV infected cells to the cytoplasm.