VZV ORF40, the major capsid protein, is a homomultimer that self-assembles to form an icosahedral capsid (UniProtKB – Q4JQT5). Its HSV-1 ortholog is UL19. Nagel et al (J. Virol. March 2011 vol. 85 no. 5 2276-2287) detected 10 VZV transcripts in latently infected human trigeminal ganglia in the following order of prevalence: ORF 63 (69%), ORF 29 (38%), ORF 4 (31%), ORF 62 (27%), ORF 11 (27%), ORF 68 (23%), ORF 40 (15%), ORF 43 (8%), ORF 41 (4%), and ORF 57 (4%). The ORF40 has calculated molecular weight of 115 kDa and our monoclonal antibody VZ 40.1.03 confirmed a 115 kDa protein in western blot. Our anti-VZV ORF40 antibody VZ 40.1.03 works in ELISA (on immunogen) and each LOT is validated for Western blot (of VZV infected cell lysates, described in J Virol. 2013 Jun;87(12):6943-54.).
Clone: VZ 40.1.03
Catalog No.: HR-VZV-40
Host Species: Mouse
Reactivity: Varicella zoster virus
Antigen/Immunogen: The immunogen consisted of ORF40 N terminal domain (amino acids: 1-500) and was produced in E.coli
Tested Applications: ELISA; WB
Varicella zoster virus
The immunogen consisted of ORF40 N terminal domain (amino acids: 1-500) and was produced in E.coli
€120.00 – €500.00
|STORAGE||Long term -20 °C, short term +4 °C. Avoid freeze-thaw cycles.|
|LIGHT CHAIN TYPE||kappa|
|REFERENCES||Lenac et al., J Virol, 2013|
VZV ORF27 encodes a nuclear egress lamina protein, that together with the nuclear egress membrane protein encoded by the product of VZV ORF27, most likely plays a role in the egress of assembled viral capsids from the nuclei of VZV infected cells to the cytoplasm.