VZV ORF36 is present in the central region of the UL segment and consists of 1026 nucleotides. The encoded 38 kDa thymidine kinase (TK) protein mediates the transfer of gamma-phospho-group from ATP to thymidine, forming dTMP which is then used by DNA polymerase for viral replication. TK is essential in maintaining VZV replication both in infection and latency, and its active sites are highly conserved among all herpesviruses. Our anti-VZV ORF36 antibody VZ 36.14 works in ELISA (on immunogen) and each LOT is validated for Western blot where it specifically recognized a protein of 38 kDa in lysates of VZV infected cells (described in J Virol. 2013 Jun;87(12):6943-54).
Clone: VZ 36.14
Catalog No.: HR-VZV-24
Host Species: Mouse
Reactivity: Varicella zoster virus
Antigen/Immunogen: The immunogen consisted of full length ORF36 and was produced in E.coli
Tested Applications: ELISA; WB
Recommended Dilution: n/a
Varicella zoster virus
The immunogen consisted of full length ORF36 and was produced in E.coli
€200.00 – €700.00
|STORAGE||Long term -20 °C, short term +4 °C. Avoid freeze-thaw cycles.|
|LIGHT CHAIN TYPE||kappa|
|REFERENCES||Lenac et al., J Virol, 2013|
VZV ORF4 encodes an IE4 protein that acts as transactivator of several immediate early, early and late VZV genes. Dimerization of IE4 is required for its transactivation function.
VZV ORF24 encodes a 30 kDa type 2 membrane protein that, together with the product of VZV ORF27, likely has a function in the transport (egress) of assembled viral capsids from the nuclei of VZV infected cells to the cytoplasm.
VZV ORF18 (UniProtKB – Q6QCN7) encodes a small subunit of the viral ribonucleotide reductase, which together with the large subunit, encoded by the VZV ORF19, forms the ribonucleotide reductase holoenzyme complex (RNR)
ORF48 encodes an alkaline nuclease (J Virol. 87: 11936-11938). ORF48 protein is homologous to herpes simplex type 1 (HSV-1) UL12, human cytomegalovirus (hCMV) UL98 and Epstein Barr virus (EBV) BGLF5.