The monoclonal antibody 1D6 recognises mouse MULT-1.

MULT-1 (murine UL-16 binding protein-like transcript 1) is one of the cellular stress-induced ligands for mouse NKG2D receptor. MULT-1 was discovered by the sequence homology with human UL-16 binding proteins (ULBPs). It has the highest affinity for the receptor among all known mouse NKG2D ligands (Kd = 6 nM) (Eur J Immunol 2003.33(2):381-91; J Immunol 2002. 169(8):4079-83.) Its transcripts were found in most of the healthy tissues, but its protein expression was strictly regulated on posttranslational level (J Exp Med 2009. 206(2):287–298.). It is a type I transmembrane glycoprotein with long cytoplasmic tail and protein sequence of 334 amino acids. Estimated molecular weight is 53 kDa and half-life of around 16 hours (J Exp Med 2005. 201(2):211-20.)

Our anti-MULT-1 antibody has beed validated in ELISA (on cell lysates), in IP (on MULT-1-HA transfectants) and in flow cytometry on several different cell lines as described in references.

FORM	Liquid
STORAGE	Long term -20 °C, short term +4 °C. Avoid freeze-thaw cycles.
CONCENTRATION	1 mg/mL
PURITY	Affinity purified
CLONALITY	Monoclonal
ISOTYPE	IgG2a
LIGHT CHAIN TYPE	kappa
REFERENCES	Front Immunol 2018. 9:991., Front Immunol 2019. 10:154., J Exp Med 2005. 201(2):211-20., J Exp Med 2009. 206(2):287-98., J Immunol 2010. 185(9):5369-76., Nat Commun 2017. 8:13930., Science 2015. 348(6230):136-9.

Protocols