The monoclonal antibody mPVR.13 recognizes mouse PVR, also known as poliovirus receptor, Necl-5 or CD155.
PVR is a 70 kD type I transmembrane glycoprotein, member of the nectin-like family of proteins, belonging to Ig superfamily. PVR was originally identified based on its ability to mediate poliovirus entry. The normal cellular function includes involvement in cell adhesion, contact inhibition and proliferation via interaction with other members of nectin family of proteins and substantial immunoregulatory function via interaction with immune cell receptors DNAM-1, TIGIT and CD96. PVR is expressed in low levels on the majority of somatic cells under physiological conditions but is dramatically overexpressed on tumor cells.
Our anti-PVR antibody mPVR.13 has been validated in WB (cell lysate and immunogen) and in flow cytometry (mouse cells).