m155 is a mouse cytomegalovirus (MCMV) 43-kDa glycoprotein expressed in endoplasmic reticulum and cis-Golgi compartment of infected cells (Loewendorf et al., 2011, Journal of Virology, 85(10), 5208–5212). It is a member of m145 family of MCMV proteins that exhibits structural homology to MHC class I molecules and is shown to participate in viral immune evasion by inhibiting NK cell ligand H60 (Lodoen et al., 2004, J. Exp. Med, 10700(8), 1075–1081). It also downregulates the expression of CD40 in infected antigen-presenting cells, therefore inhibiting the priming of normal CD4 T cell response (Loewendorf et al., 2011, Journal of Virology, 85(10), 5208–5212). Our anti-M155 antibody m155N.01 works in ELISA (on immunogen) and each LOT is validated for Western blot (of MCMV infected cell lysates).
Catalog No.: HR-MCMV-09
Host Species: Mouse
Reactivity: Murine cytomegalovirus
Antigen/Immunogen: The immunogen consisted of N-terminal portion of m155 and was produced in E.coli
Tested Applications: ELISA; WB
Recommended Dilution: n/a
The immunogen consisted of N-terminal portion of m155 and was produced in E.coli
€200.00 – €700.00
|STORAGE||Long term -20 °C, short term +4 °C. Avoid freeze-thaw cycles.|
|LIGHT CHAIN TYPE||kappa|
Murine cytomegalovirus immediate-early 1 (IE1, pp89, m123) is one of the first proteins expressed during productive (lytic) infection as well as during reactivation from the latency.
MCMV early protein 1 (E1), encoded by murine cytomegalovirus (MCMV) M112-113 gene region localizes predominately to the nucleus of MCMV-infected cells (Ciocco-Schmitt et al., 2002, Virology, 294, 199–208.).
Murine cytomegalovirus m152 is an ER resident type I transmembrane protein that retains MHC I and NKG2D ligands Rae-1 proteins in the ER and thus aids virally infected cells in evading NK and T cells.
M45 is a 97-kDa virion-associated protein encoded by mouse cytomegalovirus (MCMV) (Krause et al., 2014, Journal of Virology, 88(17), 9963–9975; Rawlinson et al., 1996, Journal of Virology, 70(10), 8833–8849).