Anti-m06 (MCMV) antibody
Clone: CROMA 229
Catalog No.: HR-MCMV-02
Host Species: Mouse
Reactivity: Murine cytomegalovirus
Antigen/Immunogen: MCMV virions
Tested Applications: FACS, WB
€200.00 – €1,500.00
Anti-m06 (MCMV) antibody
Western Blot Lysates of cells: a=uninfected cells b=MCMV infected cells
Anti-m06 (MCMV) antibody
Overlay histogram showing MEF-K cells infected with d138 MCMV, stained with 1:100 Ab m06 (red line) and 1:100 FITC-conjugated anti-mouse IgG. Isotype control antibody (black line) was mouse IgG used under the same conditions.
Anti-m06 (MCMV) antibody
Overlay histogram showing MEF-K cells infected with d138 MCMV, stained with 1:100 Ab m06 (red line) and 1:100 FITC-conjugated anti-mouse IgG. Isotype control antibody (black line) was mouse IgG used under the same conditions.
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Description
The monoclonal antibody CROMA229 recognizes MCMV protein m06, also known as gp48.
m06 is a 48-kDa type I transmembrane glycoprotein, member of MCMV m04-m16 family that plays a role in MHC-I trafficking and immune evasion. m06 has early kinetics of expression (3h), peaking at 3–6 h post infection (Reusch, U. et al, The EMBO Journal. 1999). Unlike m04, this glycoprotein binds stably to MHC-I complexes in the ER transferring them via the Golgi apparatus to the trans-Golgi network and redirecting MHC I complexes to lysosomes for degradation, thus preventing their surface expression.
Our anti-m06 antibody has been validated in WB (MCMV infected cell lysates) and in intracellular flow cytometry (MCMV infected cells).
Additional information
| FORM | Liquid |
|---|---|
| STORAGE | Long term -20 °C, short term +4 °C. Avoid freeze-thaw cycles. |
| CONCENTRATION | 1 mg/mL |
| PURITY | Affinity purified |
| CLONALITY | Monoclonal |
| ISOTYPE | IgG1 |
| LIGHT CHAIN TYPE | kappa |
| REFERENCES | Journal of Experimental Medicine (2009) 206, 515-523, Nature Immunology (2002) 3, 529-535, The EMBO Journal (1999) 18, 1081 - 1091 |
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